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Friday, 10 April 2020
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Articles

nanoparticles bbb brain 200 nmNanoparticles go through BBB

Blood-brain barrier was shown to be permeable for particles as big as >200 nm, a group of scientists from Johns Hopkins University show. The article of Nance et al. in Sci Transl Med (DOI: 10.1126/scitranslmed.3003594) describes how a highly dense PEG coating can make nanoparticles diffuse in a brain. The previously thought to be impermeable for any particles with diameters bigger than ca. 60 nm, the BBB seemed not to be able to block the particles of almost a triple size, if these were coated with a sufficient amount of PEG. Study of diffusion kinetics suggests that over 50% of the pores in BBB can be passed by 100-nm particles, and 25% - by particles as large as 200 nm in case the particles do not adhere to the endothelial cells of the BBB.

The trick of making the particles to glide “undetected” through the BBB is by anchoring at least nine 5000 Da PEG molecules per 100 nm2 of the surface. Successful in vitro experiments on human and rat brain tissues as well as in the rat in vivo experiments opens new opportunities for the creation of novel drug formulations against brain cancer, CNS deseases or conditions associated with a disrupted BBB.

NanoJam, 2012-10-21

 

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