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Saturday, 19 October 2019
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Chemistry: Giant hyperthermal effect in Mg-doped Fe3O4 - Friday, 09 February 2018 11:36
Biology: Nanodiamonds for antibacterial implants - Monday, 02 November 2015 21:41
Ecology: Nano-products risks overexaggerated - Tuesday, 24 June 2014 11:02

nanodiamonds implants root canalWhile nanodiamonds are known already for a while, the new research revokes the interest in these tiny particles in medical applications. Inspired by former findings that nanodiamonds improve the mechanical properties of polymers, including dental implants (Dental Materials Journal, 2011; 30(2):222), researchers from the University of California, have decided to try nanodiamonds in root canal implants, which are usually made of mechanically poor gutta percha. In parallel, amoxicillin, an antibiotic molecule was added to the polymer. A parallel experiment with the same compound, but without an antibiotic was made. To the surprize of the authors, aside of the great increase in the mechanical strength of the polymer, pure nanodiamonds without the drug have also demonstrated a strong antibacterial effectiveness. This finding recently published in ACS Nano ( opens a previously unknown potential of diamond nanoparticles to be used in endodontic therapy as well as probably in other types of implants.

nanodiamonds bactericide acs nano 2014Materials scientists from Bremen and Stanford have shown that nanodiamonds are an effective bacteria killer, the article was recently published in ACS Nano.

Nanodiamonds are tiny diamond crystals of a diameter of 5 nanometers, about 200 times smaller than a bacterium. A group of scientists from Bremen and Stanford University identified the strong antibacterial properties of these nanodiamonds. In addition to silver and copper, the diamond could be used as new effective agent against bacterial infections.

Nanodiamonds were discovered in the 1960s by Russian scientists, but only recently became widely acknowledged for their extraordinary properties. The surface of these particles can be modified with various chemical groups. The biologist Julia Wehling and the chemist and project manager Dr. Michael Maas found that some types of nanodiamonds are extremely effective against both Gram-positive and negative bacteria. In an exciting research, the scientists identified that certain oxygen-containing groups on the surfaces of nanodiamonds (acid anhydrides) are responsible for the antibacterial activity of the particles.
"The comprehension that nanodiamonds are similarly effective in killing bacteria as silver opens up a variety of possible applications in the field of medical technology and materials science. At the same time we see that the nanodiamonds used at the concentration tested are not toxic to human cells. Thus, coatings of surfaces or the addition of nanodiamond to disinfectants becomes feasible. In the era of antibiotic resistance, the discovery of a novel antibacterial material is a breakthrough", emphasizes Julia Wehling the importance of the discovery.
The project manager Dr. Michael Maas became aware of nanodiamonds during his visit at Stanford University in California in his conversation with Professor Richard N. Zare. "Upon my return, we have begun to use nanodiamonds in various nano-systems, which we examined in Bremen. We were surprised at how efficient they were in killing bacteria. It is obvious that in the nearest future these particles will play an important role as an antibacterial material. Our next goal is to test the nanodiamonds as an additive to implants, thus providing them antiseptic properties. Parallel to this a more detailed characterization of the nanodiamond surface will be performed."

Details of this research is available in the original publication that appeared online end of May 2014.

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Nanotechnology for drug delivery shows promise in treatment of pediatric leukemia

Link to the nanodiamonds used in the study: PlasmaChem

Image courtesy: ACS Nano

ZnO nanoparticlesPUNE: In a breakthrough discovery, scientists at the Agharkar Research Institute (ARI) here have shown that zinc oxide nanoparticles could be used for treating both non-insulin dependent (Type I) and insulin dependent (Type II) diabetes. What's more important is that the drug is patient-friendly as just one pill a day will keep blood sugar levels under control. The scientists have successfully carried out laboratory tests on rats and the study has been published in the renowned medical journal Nanomedicine on February 21.

nanoparticles-cell-interactionCells and Nanoparticles: the effect of biological corona

The interactions between nano-sized particles and living systems are commonly mediated by what adsorbs to the nanoparticle in the biological environment, its „biomolecular corona‟, rather than the pristine surface. In the just accepted manuscript of Anna Lesniak with coauthors, the adhesion of nanoparticles of different material and size towards the cell membrane was characterized, and studied how this is modulated by the presence or absence of a corona on the nanoparticle surface. The results were corroborated with adsorption to simple model supported lipid bilayers using a quartz crystal microbalance. It was conclude that the adsorption of proteins on the nanoparticle surface strongly reduces nanoparticle adhesion in comparison to what is observed for the bare material.

Calcium carbonate templates for drug delivery

kalkschablone standardMicrocontainers for medical substances can be produced in different sizes using calcium carbonate microspheres as templates

The fast and targeted delivery of drugs to the focus of a disease could soon be made easier. Helmuth Möhwald and his colleagues from the Max Planck Institute of Colloids and Interfaces in Potsdam-Golm have developed a simple technique for the production of drug containers which can be channelled to a selected target in the body. The researchers use porous calcium carbonate microspheres as templates for the production of hollow three-dimensional balls. These can absorb medically effective substances and allow signalling molecules to be attached to their surface, with the help of which the spheres can then find their way to the diseased tissue.

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