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Tuesday, 28 January 2020
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nanoparticles-cell-interactionCells and Nanoparticles: the effect of biological corona

The interactions between nano-sized particles and living systems are commonly mediated by what adsorbs to the nanoparticle in the biological environment, its „biomolecular corona‟, rather than the pristine surface. In the just accepted manuscript of Anna Lesniak with coauthors, the adhesion of nanoparticles of different material and size towards the cell membrane was characterized, and studied how this is modulated by the presence or absence of a corona on the nanoparticle surface. The results were corroborated with adsorption to simple model supported lipid bilayers using a quartz crystal microbalance. It was conclude that the adsorption of proteins on the nanoparticle surface strongly reduces nanoparticle adhesion in comparison to what is observed for the bare material.

Nanoparticle uptake was described as a two-step process, where the nanoparticles initially adhere to the cell membrane and subsequently are internalised by the cells via energy-dependent pathways. The lowered adhesion in the presence of proteins thereby caused a concomitant decrease in nanoparticle uptake efficiency.

"The presence of a biomolecular corona may confer specific interactions between the nanoparticle-corona complex and the cell surface, including triggering of regulated cell uptake. An important effect of the corona is, however, a reduction in the purely unspecific interactions between the bare material and the cell membrane, which in itself disregarding specific interactions, causes a decrease in cellular uptake."

Authors suggested that future nanoparticle-cell studies must include, together with characterisation of size, charge and dispersion stability, an evaluation of the adhesion properties of the material to relevant membranes.

Read the full article in the Journal of the American Chemical Society, DOI: 10.1021/ja309812z

Source: image adopted with the permission of the ACS

Related articles on the cells/nanoparticles interactions and toxicity:

Hydrophobicity of nanoparticles influences their toxicity

Nanoparticles go through BBB

Are nanoparticles really so toxic?

2013-01-17 NanoJam (C)


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